The tennis star lost to No. 16 Anastasija Sevastova.
Maria Sharapova played in Swarovski-embellished Riccardo Tisci at her first match of the 2017 U.S. Open.
The Nike athlete and five-time Slam winner said she “fought hard for the truth.”
Sharapova hasn’t competed since the Australian Open in January 2016.
The tennis star received notice in March that she had tested positive at the Australian Open for the newly banned substance meldonium.
“We hope to see Maria back on court and will continue to partner with her,” Nike said in statement.
The Nike athlete said she will appeal the suspension.
Tag Heuer and Porsche have also distanced themselves from the tennis star after she failed a drug test.